Nonsense mutations in the C-terminal SH2 region of the GTPase activating protein (GAP) gene in human tumours.

doi:10.1038/ng1193-242

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Article

Nonsense mutations in the C-terminal SH2 region of the GTPase activating protein (GAP) gene in human tumours.

Nature genetics - 1 Nov 1993

Friedman E, Gejman P V, Martin G A, McCormick F

Abstract excerpt

GTPase Activating Protein (GAP) is involved in down-regulating normal ras proteins and in the signal transduction pathway of some growth factors. We have screened 188 human tumours for mutations in the catalytic domain and at the C terminal SH2 region GAP. Three nonsense mutations in basal cell c...

Topics

Amino Acid Sequence
Base Sequence
Binding Sites
Catalysis
DNA Primers
DNA, Neoplasm
GTPase-Activating Proteins
Humans
Molecular Sequence Data
Mutation
Neoplasms
Polymerase Chain Reaction
Proteins
ras GTPase-Activating Proteins

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