Article
Polyethylene-glycol-mediated delivery of liposome-entrapped pigments into fibroblasts: experimental pigment cells as models for mutator phenotypes.
Cancer research - 1 Dec 1992
Schmitz S, Allen T M, Jimbow K
Abstract excerpt
The role of epidermal melanin pigments in the development of skin cancer remains unclear. A new technique for the specific introduction of compartmentalized melanin into nonpigmented human fibroblasts through the use of liposomes and polyethylene glycol (PEG) is presented. The delivery of liposom...
Topics
- Cell Compartmentation
- Cells, Cultured
- Cytosol
- Drug Carriers
- Fibroblasts
- Fluoresceins
- Humans
- Hydrogen-Ion Concentration
- Indicators and Reagents
- Liposomes
- Melanins
- Microscopy, Electron
- Microscopy, Fluorescence
- Mutation
- Phenotype
- Pigmentation
- Polyethylene Glycols
- Temperature