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Reconstructed human pigmented skin/epidermis models achieve epidermal pigmentation through melanocore transfer

24 Mar 2022

Abstract excerpt

The skin acts as a barrier to environmental insults and provides many vital functions. One of these is to shield DNA from harmful ultraviolet radiation, which is achieved by skin pigmentation arising as melanin is produced and dispersed within the epidermal layer. This is a crucial defence against DNA damage, photo-ageing and skin cancer. The mechanisms and regulation of melanogenesis and melanin transfer involve...

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PMID: 35325505
DOI: 10.1111/pcmr.13039

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