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Article

Expression of resistance to etoposide and vincristine in vitro and in vivo after X-irradiation of ovarian tumor cells.

Anti-cancer drugs - 1 Aug 1992

Dempke W C, Whelan R D, Hill B T

Abstract excerpt

Two human ovarian carcinoma cell lines (JA-T/P and SK-OV-3/P) were exposed to 10 fractions of 5 Gy X-irradiation in vitro. Surviving populations generated sublines designated DXR-10 which expressed significant resistance to etoposide (VP-16) and vincristine (VCR), but not to adriamycin (ADR) or acute X-irradiation, as judged by clonogenic assays. JA-T/P and JA-T/DXR-10 tumor cells were xenografted into nude mice...

Topics

Animals
Drug Resistance
Drug Screening Assays, Antitumor
Etoposide
Female
Humans
Mice
Mice, Nude
Neoplasm Transplantation
Ovarian Neoplasms
Phenotype
Transplantation, Heterologous

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Cells, Cultured

Vincristine

Source

Identifiers

PMID: 1421436
DOI: 10.1097/00001813-199208000-00013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1421436-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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