Variation of pharmacokinetics after oral administration of slow-release metoprolol tablets and pharmacogenetic considerations.

Article

Variation of pharmacokinetics after oral administration of slow-release metoprolol tablets and pharmacogenetic considerations.

Arzneimittel-Forschung - 1 Jun 1992

Shimizu H, Noguchi H, Uno K

Abstract excerpt

The maximum plasma concentrations (Cmax) after oral administration of 120 mg tablets of slow-release metoprolol (CAS 37350-58-6) to 75 Japanese healthy male volunteers and 15 arrhythmic patients were measured. Extensive and poor metabolizers after oral administrations of slow-release metoprolol t...

Topics

Administration, Oral
Adult
Asian People
Chromatography, High Pressure Liquid
Delayed-Action Preparations
Humans
Japan
Male
Metoprolol
Middle Aged
Pharmacogenetics
Phenotype
Tablets
United Kingdom
White People

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