Article
The Nb2 form of prolactin receptor is able to activate a milk protein gene promoter.
Molecular endocrinology (Baltimore, Md.) - 1 Aug 1992
Ali S, Edery M, Pellegrini I, Lesueur L, Paly J, Djiane J, Kelly P A
Abstract excerpt
We have recently cloned a cDNA encoding a mutant form of PRL receptor (PRL-R) from Nb2 cells, a PRL-dependent T lymphocyte-derived cell line. This cDNA is identical to the long form of the rat PRL-R, except for a deletion of 594 base pairs in the cytoplasmic domain, resulting in a mature receptor protein of 393 amino acids. Although a segment containing three cytoplasmic regions of moderate to high amino acid...
Topics
- Animals
- CHO Cells
- Caseins
- Cricetinae
- DNA
- Gene Deletion
- Gene Expression Regulation
- Mutation
- Prolactin
- Promoter Regions, Genetic
- Rats
- Receptors, Prolactin