Transcriptional activity of a mutant thyroid hormone receptor beta in a family with generalized resistance to thyroid hormone.

doi:10.1016/0303-7207(92)90108-i

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Article

Transcriptional activity of a mutant thyroid hormone receptor beta in a family with generalized resistance to thyroid hormone.

Molecular and cellular endocrinology - 1 Dec 1992

Shuto Y, Okazaki T, Wakabayashi I

Abstract excerpt

We previously reported a family with generalized resistance to thyroid hormone (GRTH) which had a point mutation with codon 448 CCT (proline) being converted to ACT (threonine) in the thyroid hormone receptor (TR) beta. To characterize functional properties of the mutant TR beta, transient expres...

Topics

Animals
Base Sequence
Cells, Cultured
Chlorocebus aethiops
Codon
DNA
Genes, Synthetic
Humans
Molecular Sequence Data
Mutation
Promoter Regions, Genetic
Protein Binding
Rats
Receptors, Thyroid Hormone
Recombinant Fusion Proteins
Regulatory Sequences, Nucleic Acid
Thymidine Kinase
Thyroid Hormones

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Open in PubMed

Identifiers

PMID: 1301392
DOI: 10.1016/0303-7207(92)90108-i

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1301392-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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