Article
[Effect of mutant genes db(diabetes) and m(misty) on the severity of high-dose streptozotocin diabetes in C57bl/KsJY mice].
TSitologiia i genetika - 1 Jan 2000
Blokh K O, Poltorak V V, Brindak O I
Abstract excerpt
It is stated that high-dose streptozotocin diabetes is more serious in gene db-homozygous mice of mutant line C57BL/KsJY than in heterozygotes db +/+ m and mice M+/+m. Manifestation of spontaneous insulin-independent diabetes mellitus in homozygotes db decreases the level of hyperglycemic streptozotocin-induced reactions.
Topics
- Animals
- Diabetes Mellitus, Experimental
- Heterozygote
- Homozygote
- Male
- Mice
- Mice, Mutant Strains
- Mutation
- Severity of Illness Index