Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis.

1 Oct 1992

Abstract excerpt

During human immunodeficiency virus (HIV) infection there is a profound and selective decrease in the CD4+ population of T lymphocytes. The mechanism of this depletion is not understood, as only a small fraction of all CD4+ cells appear to be productively infected with HIV-1 in seropositive individuals. In the present study, crosslinking of bound gp120 on human CD4+ T cells followed by signaling through the T...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV Research and Treatment
Share to Immune Cell Function and Interaction
Share to Mosquito-borne diseases and control

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1402655
DOI: 10.1084/jem.176.4.1099

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis.PMID 1402655Read ↗

Mechanisms of Human Immunodeficiency Virus-Associated Lymphocyte Regulated Cell DeathSemantic proximity Read ↗

Mechanisms of HIV-associated lymphocyte apoptosis: 2010Semantic proximity Read ↗

Programmed Death of T Cells in HIV-1 InfectionSemantic proximity Read ↗

Accelerated apoptosis in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus type-1 infected patients and in CD4 cross-linked PBMCs from normal individuals.Semantic proximity Read ↗

HIV-1 Env Glycoprotein Phenotype along with Immune Activation Determines CD4 T Cell Loss in HIV Patients.Semantic proximity Read ↗

Modulation of apoptosis and viral latency – an axis to be well understood for successful cure of human immunodeficiency virusSemantic proximity Read ↗

Programmed cell death in peripheral lymphocytes from HIV-infected persons: increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progressionSemantic proximity Read ↗

Distinct mechanisms trigger apoptosis in human immunodeficiency virus type 1-infected and in uninfected bystander T lymphocytes.Semantic proximity Read ↗

Inhibition of Envelope-Mediated CD4<sup>+</sup>-T-Cell Depletion by Human Immunodeficiency Virus Attachment InhibitorsSemantic proximity Read ↗

Role of Fas Ligand and Receptor in the Mechanism of T-Cell Depletion in Acquired Immunodeficiency Syndrome: Effect on CD4+ Lymphocyte Depletion and Human Immunodeficiency Virus ReplicationSemantic proximity Read ↗

Decreased T cell apoptosis and T cell recovery during highly active antiretroviral therapy (HAART).Semantic proximity Read ↗

HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.