Article
Suppression of human nasopharyngeal carcinoma cell growth in nude mice by the wild-type p53 gene.
Journal of cancer research and clinical oncology - 1 Jan 1992
Chen W, Lee Y, Wang H, Yu G G, Jiao W, Zhou W, Zeng Y
Abstract excerpt
Wild-type and mutant human p53 genes were transfected into the nasopharyngeal carcinoma (NPC) cell line CNE-3. Tumorigenicity in nude mice showed that the tumor resulting from the cells transfected with the wild-type p53 gene grew more slowly and was smaller than that from the cells transfected with mutant p53 gene and that from control CNE-3 cells. In contrast, the tumor from the cells transfected with the...
Topics
- Animals
- Cell Line
- Genes, p53
- Humans
- Mice
- Mice, Nude
- Mutation
- Nasopharyngeal Neoplasms
- Transfection