Article
Tumor-suppressive activity of N03 gene product in v-src-transformed rat 3Y1 fibroblasts.
Cancer research - 1 Feb 1994
Ozaki T, Sakiyama S
Abstract excerpt
The expression of the N03 gene was significantly reduced in a variety of transformed cells, compared with that in parental rat 3Y1 fibroblasts. To understand the possible role(s) of its product, we have obtained transfectants expressing N03 gene from v-src-transformed 3Y1 cells. Two clones, which overexpressed N03 mRNA, showed a flatter phenotype, a reduced rate of growth, and a decreased ability to grow in soft...
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