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Article

Combined CYP1A1/GSTM1 at-risk genotypes are overrepresented in squamous cell lung carcinoma patients but underrepresented in elderly tumor-free subjects.

Journal of cancer research and clinical oncology - 1 May 2006

Belogubova Evgeniya V, Ulibina Yulia M, Suvorova Irina K, Kuligina Ekatherina Sh, Karpova Maria B, Shutkin Vladimir A, Koloskov Andrey V, Kuchinskiy Alexandr P, Togo Alexandr V, Hanson Kaido P, Hirvonen Ari, Imyanitov Evgeny N

Abstract excerpt

PURPOSE: Polycyclic aromatic hydrocarbons are activated by cytochrome P450 1A1 (CYP1A1) and inactivated by glutathione S-transferase mu (GSTM1). Therefore, it is expected that a combination of proficient CYP1A1 genotype with deficient GSTM1 variant would result in particularly elevated lung cancer (LC) risk, especially for squamous cell carcinoma (SCC). This study was aimed to validate whether the CYP1A1-C (3801)...

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Identifiers

PMID: 16416283
DOI: 10.1007/s00432-005-0071-7

Genes

GSTM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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