Article
Drug resistance as a dynamic process in a model for multistep gene amplification under various levels of selection stringency.
Cancer chemotherapy and pharmacology - 1 Jan 1992
Harnevo L E, Agur Z
Abstract excerpt
Resistance to antineoplastic drugs has been a major impediment to the successful treatment of cancer. Recent studies suggest that several mechanisms are responsible for the emergence of drug resistance but that high levels of resistance and poor prognosis are strongly associated with gene or oncogene amplification. In this report we describe a probabilistic model for gene amplification in a tumor that grows under...
Topics
- Antineoplastic Agents
- Antineoplastic Combined Chemotherapy Protocols
- Cell Death
- Drug Resistance
- Gene Amplification
- Humans
- Models, Biological
- Models, Statistical
- Mutation
- Neoplasms
- Phenotype