Article
High-level resistance to cycloheximide resulting from an interaction of the mutated pdr3 and cyh genes in yeast.
Current genetics - 1 Oct 1992
Ruttkay-Nedecký B, Obernauerová M, Subík J
Abstract excerpt
In addition to pdr3-1, the S. cerevisiae nuclear pleiotropic drug resistance mutant 2D was found to contain another recessive nuclear mutation, cyh, conferring specific resistance to cycloheximide only. The cycloheximide resistance level due to either the pdr3-1 or the cyh mutation alone was low and was not altered by the ogd1 mutation which increased the physiological acidification of the culture. When pdr3-1...
Topics
- Cycloheximide
- Drug Resistance, Microbial
- Gene Expression
- Genes, Fungal
- Mutation
- Saccharomyces cerevisiae