Use of mutated PDR3 gene as a dominant selectable marker in transformation of prototrophic yeast strains.

Abstract excerpt

For successful transformation of prototrophic industrial yeast strains dominant selectable markers are necessary. In the present study we show the applicability of a selection system based on the phenotype of multidrug resistance. The mutant pdr3-9 allele on centromeric or episomal vector, encoding a more efficient transcriptional activator with Y276H amino acid substitution, was used as a dominant selectable...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antifungal Agents
• Share to Drug Resistance, Microbial
• Share to Drug Resistance, Multiple