Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog.

doi:10.1016/0092-8674(92)90264-d

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Article

Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog.

Cell - 2 Oct 1992

Lee J J, von Kessler D P, Parks S, Beachy P A

Abstract excerpt

The segment polarity genes engrailed and wingless are expressed in neighboring stripes of cells on opposite sides of the Drosophila parasegment boundary. Each gene is mutually required for maintenance of the other's expression; continued expression of both also requires several other segment polarity genes. We show here that one such gene, hedgehog, encodes a protein targeted to the secretory pathway and is...

Topics

Amino Acid Sequence
Animals
Base Sequence
Blotting, Northern
Blotting, Southern
Drosophila
Drosophila Proteins
Gene Expression Regulation
Genes, Insect
Hedgehog Proteins
Larva

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Polymerase Chain Reaction

Proteins

Restriction Mapping

Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 1394430
DOI: 10.1016/0092-8674(92)90264-d

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1394430-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog.PMID 1394430Read ↗

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The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation.Semantic proximity Read ↗

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smoothened encodes a receptor-like serpentine protein required for hedgehog signalling.Semantic proximity Read ↗

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