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Article

CPT-11 in human colon-cancer cell lines and xenografts: Characterization of cellular sensitivity determinants

27 Jan 1997

Abstract excerpt

CPT-11, a new semisynthetic derivative of camptothecin, is active in a number of tumor types in the clinic, including colon cancer. CPT-11 is a drug that is converted into the active metabolite SN-38 by a carboxylesterase. Experiments were performed to obtain more insight in the cellular characteristics in 5 unselected human colon-cancer cell lines that account for the differential sensitivity to CPT-11 and...

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Identifiers

PMID: 9033637
DOI: 10.1002/(sici)1097-0215(19970127)70:3<335::aid-ijc15>3.0.co;2-e

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CPT-11 in human colon-cancer cell lines and xenografts: Characterization of cellular sensitivity determinantsPMID 9033637Read ↗

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