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Article

Evidence for spontaneous conversion of Mex- to Mex+ in human lymphoblastoid cells.

Carcinogenesis - 1 Oct 1990

Arita I, Fujimori A, Takebe H, Tatsumi K

Abstract excerpt

A series of human lymphoblastoid cell lines (LCLs) called Mex- were defined by Sklar and Strauss on the basis of their inability to remove O6-methylguanine from DNA. Instability of Mex- has previously been shown as a population phenotype of LCLs. We examined whether Mex- as a cellular phenotype is spontaneously convertible or not. At the population doubling number (PDN) 23 after recloning, two out of 15...

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Identifiers

PMID: 2208588
DOI: 10.1093/carcin/11.10.1733

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Evidence for spontaneous conversion of Mex- to Mex+ in human lymphoblastoid cells.PMID 2208588Read ↗

Epigenetic silencing of the DNA repair enzyme O6-methylguanine-DNA methyltransferase in Mex- human cells.Semantic proximity Read ↗

Genomic differences between O6-methylguanine-DNA methyltransferase proficient (Mex+) and deficient (Mex-) cell lines: possible role of genetic and epigenetic changes in conversion of Mex+ into Mex-.Semantic proximity Read ↗

Strange Stable Replicators Generated From Mumps Virus cDNA ClonesSemantic proximity Read ↗

Molecular and cellular characterization of Mex-/methylation-resistant phenotype. Gene and cDNA cloning, serum dependence, and tumor suppression of transfectant strains.Semantic proximity Read ↗

Coregulation of the human O6-methylguanine-DNA methyltransferase with two unrelated genes that are closely linked.Semantic proximity Read ↗

Sensitivity to the parvovirus minute virus of mice as a probe for azatyrosine-mediated phenotypic reversion of spontaneously transformed cells.Semantic proximity Read ↗

Spontaneous mutation rates in mammalian cells: effect of differential growth rates and phenotypic lag.Semantic proximity Read ↗

An Alu‐like RNA promotes cell differentiation and reduces malignancy of human neuroblastoma cellsSemantic proximity Read ↗

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