Evidence for spontaneous conversion of Mex- to Mex+ in human lymphoblastoid cells.

doi:10.1093/carcin/11.10.1733

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Article

Evidence for spontaneous conversion of Mex- to Mex+ in human lymphoblastoid cells.

Carcinogenesis - 1 Oct 1990

Arita I, Fujimori A, Takebe H, Tatsumi K

Abstract excerpt

A series of human lymphoblastoid cell lines (LCLs) called Mex- were defined by Sklar and Strauss on the basis of their inability to remove O6-methylguanine from DNA. Instability of Mex- has previously been shown as a population phenotype of LCLs. We examined whether Mex- as a cellular phenotype i...

Topics

Cell Line
Cell Survival
Clone Cells
Gene Conversion
Guanine
Humans
Karyotyping
Methyltransferases
Nimustine
O(6)-Methylguanine-DNA Methyltransferase
Phenotype

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