Fetal compensation of the hemolytic anemia in mice homozygous for the normoblastosis (nb) mutation.

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Article

Fetal compensation of the hemolytic anemia in mice homozygous for the normoblastosis (nb) mutation.

Blood - 15 Oct 1992

Peters L L, Birkenmeier C S, Barker J E

Abstract excerpt

The mouse autosomal recessive mutation nb causes a deficiency of erythroid ankyrin and generates a life-threatening hemolytic anemia in adult mice; however, at birth, nb/nb mice appear to be robust and show no pallor. In our study, the time of disease onset was sought by comparison of nb/nb and +/? mice both in utero and postnatally. Erythroid ankyrin messenger RNA (mRNA) is expressed in fetal erythroid...

Topics

Aging
Anemia, Hemolytic
Animals
Animals, Newborn
Ankyrins
Erythrocyte Count
Erythrocytes
Erythroid Precursor Cells
Fetus
Gene Expression
Homozygote
Iron

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver

Mice

Mice, Inbred C57BL

Mice, Mutant Strains

Microscopy, Electron, Scanning

Mutation

Source

Open in PubMed

Identifiers

PMID: 1391963

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1391963-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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