Ankyrin and the hemolytic anemia mutation, nb, map to mouse chromosome 8: presence of the nb allele is associated with a truncated erythrocyte ankyrin.

doi:10.1073/pnas.87.8.3117

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Article

Ankyrin and the hemolytic anemia mutation, nb, map to mouse chromosome 8: presence of the nb allele is associated with a truncated erythrocyte ankyrin.

Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1990

White R A, Birkenmeier C S, Lux S E, Barker J E

Abstract excerpt

Mice with normoblastosis, nb/nb, have a severe hemolytic anemia. The extreme fragility and shortened lifespan of the mutant erythrocytes result from a defective membrane skeleton. Previous studies in our laboratory indicated a 50% deficiency of spectrin and an absence of normal ankyrin in erythro...

Topics

Alleles
Anemia, Hemolytic
Animals
Ankyrins
Blood Proteins
Chromosome Mapping
Chromosomes, Human, Pair 8
Crosses, Genetic
Erythrocyte Membrane
Erythrocytes
Female
Genetic Linkage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Isoenzymes

Male

Membrane Proteins

Mice

Mice, Inbred C57BL

Source

Open in PubMed Open full text

Identifiers

PMID: 2139228
DOI: 10.1073/pnas.87.8.3117
PMCID: PMC53845

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2139228-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Ankyrin and the hemolytic anemia mutation, nb, map to mouse chromosome 8: presence of the nb allele is associated with a truncated erythrocyte ankyrin.PMID 2139228Read ↗

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