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Article

Distinct fetal Ank-1 and Ank-2 related proteins and mRNAs in normal and nb/nb mice.

Blood - 15 Apr 1993

Peters L L, Turtzo L C, Birkenmeier C S, Barker J E

Abstract excerpt

Mice homozygous for the mutation normoblastosis (gene symbol nb on chromosome 8) are deficient in erythroid ankyrin (ANK-1) and have a severe hemolytic anemia throughout life. Characteristic of the disease is a dramatic decrease in the level of expression of the Ank-1 gene (chromosome 8). The other major ankyrin transcript, brain ankyrin (Ank-2 on chromosome 3) is expressed at normal levels in nb/nb mice....

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PMID: 8471772

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Distinct fetal Ank-1 and Ank-2 related proteins and mRNAs in normal and nb/nb mice.PMID 8471772Read ↗

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Ankyrin and the hemolytic anemia mutation, nb, map to mouse chromosome 8: presence of the nb allele is associated with a truncated erythrocyte ankyrin.Semantic proximity Read ↗

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A deep intronic mutation in the ankyrin-1 gene causes diminished protein expression resulting in hemolytic anemia in mice.Semantic proximity Read ↗

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