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Article

Metabolism of [3-13C]pyruvate in TCA cycle mutants of yeast.

Biochemistry - 22 Sept 1992

Sumegi B, McCammon M T, Sherry A D, Keys D A, McAlister-Henn L, Srere P A

Abstract excerpt

The utilization of pyruvate and acetate by Saccharomyces cerevisiae was examined using 13C and 1H NMR methodology in intact wild-type yeast cells and mutant yeast cells lacking Krebs tricarboxylic acid (TCA) cycle enzymes. These mutant cells lacked either mitochondrial (NAD) isocitrate dehydrogenase (NAD-ICDH1),alpha-ketoglutarate dehydrogenase complex (alpha KGDC), or mitochondrial malate dehydrogenase (MDH1)....

Topics

Acetates
Blotting, Western
Citric Acid Cycle
Gluconeogenesis
Isocitrate Dehydrogenase
Ketoglutarate Dehydrogenase Complex
Magnetic Resonance Spectroscopy
Malate Dehydrogenase
Mutation
Pyruvates
Pyruvic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

Source

Identifiers

PMID: 1390657
DOI: 10.1021/bi00152a006

Genes

MDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1390657-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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