Article
13C isotopologue perturbation studies of Listeria monocytogenes carbon metabolism and its modulation by the virulence regulator PrfA.
Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 2006
Eisenreich Wolfgang, Slaghuis Jörg, Laupitz Ralf, Bussemer Johanna, Stritzker Jochen, Schwarz Christine, Schwarz Roland, Dandekar Thomas, Goebel Werner, Bacher Adelbert
Abstract excerpt
The carbon metabolism of Listeria monocytogenes (Lm) EGD and the two isogenic mutant strains LmDeltaprfA and LmDeltaprfApPRFA* (showing no or enhanced expression, respectively, of the virulence factor PrfA) was determined by 13C isotopologue perturbation. After growth of the bacteria in a defined medium containing a mixture of [U-13C6]glucose and glucose with natural 13C abundance (1:25, wt/wt), 14 amino acids...
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