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Article

Drosophila alcohol dehydrogenase polymorphism and carbon-13 fluxes: opportunities for epistasis and natural selection.

Genetics - 1 Aug 1994

Freriksen A, de Ruiter B L, Scharloo W, Heinstra P W

Abstract excerpt

The influence of genetic variations in Drosophila alcohol dehydrogenase (ADH) on steady-state metabolic fluxes was studied by means of 13C NMR spectroscopy. Four pathways were found to be operative during 8 hr of ethanol degradation in third instar larvae of Drosophila. Seven strains differed by 18-25% in the ratio between two major pathway fluxes, i.e., into glutamate-glutamine-proline vs....

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Identifiers

PMID: 7982561
DOI: 10.1093/genetics/137.4.1071
PMCID: PMC1206054

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