Drosophila alcohol dehydrogenase polymorphism and carbon-13 fluxes: opportunities for epistasis and natural selection.

doi:10.1093/genetics/137.4.1071

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Article

Drosophila alcohol dehydrogenase polymorphism and carbon-13 fluxes: opportunities for epistasis and natural selection.

Genetics - 1 Aug 1994

Freriksen A, de Ruiter B L, Scharloo W, Heinstra P W

Abstract excerpt

The influence of genetic variations in Drosophila alcohol dehydrogenase (ADH) on steady-state metabolic fluxes was studied by means of 13C NMR spectroscopy. Four pathways were found to be operative during 8 hr of ethanol degradation in third instar larvae of Drosophila. Seven strains differed by 18-25% in the ratio between two major pathway fluxes, i.e., into glutamate-glutamine-proline vs....

Topics

Alanine
Alcohol Dehydrogenase
Animals
Carbon Isotopes
Citric Acid Cycle
Drosophila
Drosophila melanogaster
Epistasis, Genetic
Ethanol
Genes, Insect
Genotype
Lactates

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lactic Acid

Larva

Magnetic Resonance Spectroscopy

Malates

Polymorphism, Genetic

Selection, Genetic

Source

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Identifiers

PMID: 7982561
DOI: 10.1093/genetics/137.4.1071
PMCID: PMC1206054

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7982561-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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