RTS,S malaria vaccine efficacy and immunogenicity during Plasmodium falciparum challenge is associated with HLA genotype.

doi:10.1016/j.vaccine.2018.01.069

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Article

RTS,S malaria vaccine efficacy and immunogenicity during Plasmodium falciparum challenge is associated with HLA genotype.

Vaccine - 14 Mar 2018

Nielsen C M, Vekemans J, Lievens M, Kester K E, Regules J A, Ockenhouse C F

Abstract excerpt

Although RTS,S remains the most advanced malaria vaccine, the factors influencing differences in vaccine immunogenicity or efficacy between individuals or populations are still poorly characterised. The analyses of genetic determinants of immunogenicity have previously been restricted by relatively small sample sizes from individual trials. Here we combine data from six Phase II RTS,S trials and evaluate the...

Topics

Alleles
Clinical Trials as Topic
Genotype
HLA Antigens
Histocompatibility Testing
Humans
Immunogenicity, Vaccine
Malaria Vaccines
Malaria, Falciparum
Odds Ratio
Plasmodium falciparum
Vaccination

Source

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Identifiers

PMID: 29439870
DOI: 10.1016/j.vaccine.2018.01.069
PMCID: PMC5843576

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