Article
Mapping the CD4 binding domain of gp17, a glycoprotein secreted from seminal vesicles and breast carcinomas.
Biochemistry - 9 May 2000
Basmaciogullari S, Autiero M, Culerrier R, Mani J C, Gaubin M, Mishal Z, Guardiola J, Granier C, Piatier-Tonneau D
Abstract excerpt
gp17, a secretory CD4-binding factor isolated from the human seminal plasma, is identical to the gross cystic disease fluid protein-15, a specific marker for primary and metastatic breast tumors. We previously demonstrated that gp17 binds to CD4 with high affinity and strongly inhibits T lymphocyte apoptosis induced by sequential cross-linking of CD4 and T cell receptor (TCR). To further characterize the gp17/CD4...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.