Article
The first strand transfer during HIV-1 reverse transcription can occur either intramolecularly or intermolecularly.
Virology - 10 May 1998
van Wamel J L, Berkhout B
Abstract excerpt
Reverse transcription is a complicated process that involves at least two cDNA transfer reactions to produce a full-length copy DNA of the retroviral RNA genome. Because one retrovirus particle contains two identical genomic RNA molecules, the transfers can occur in an intramolecular or intermolecular manner. The mechanism of the first transfer step (minus-strand strong-stop cDNA transfer) has been studied...
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