[Obtaining of mutants of Streptomyces fradiae producing tylosin by action of nitrosomethylurea on synchronously germinating spores].

Article

[Obtaining of mutants of Streptomyces fradiae producing tylosin by action of nitrosomethylurea on synchronously germinating spores].

Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] - 1 May 1990

Panfilova Z I, Dubrovina N V, Tomashevskaia N A

Abstract excerpt

The method of localized mutagenesis was applied to obtain mutants of Streptomyces fradiae producing higher amounts of tylosin. The populations of the germinating spores were subjected to a short-term treatment with nitrosomethylurea during different periods of the first DNA replication cycle. The...

Topics

DNA Replication
DNA, Bacterial
Methylnitrosourea
Mutation
Spores, Bacterial
Streptomyces
Time Factors
Tylosin

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