Article
[Obtaining of mutants of Streptomyces fradiae producing tylosin by action of nitrosomethylurea on synchronously germinating spores].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] - 1 May 1990
Panfilova Z I, Dubrovina N V, Tomashevskaia N A
Abstract excerpt
The method of localized mutagenesis was applied to obtain mutants of Streptomyces fradiae producing higher amounts of tylosin. The populations of the germinating spores were subjected to a short-term treatment with nitrosomethylurea during different periods of the first DNA replication cycle. The method reveals defines periods sensitive to mutation induction and isolates a mutant producing a 60% increase in the...
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