Article
Surface epitope variation via mosaic gene formation is potential key to long-term survival of Trypanosoma brucei.
Molecular and biochemical parasitology - 1 Jul 1992
Kamper S M, Barbet A F
Abstract excerpt
Trypanosoma brucei evades the immune response of its mammalian host by antigenic variation in the major surface antigen (the variable surface glycoprotein or VSG). We examined the generation of diversity in 4 in vivo-derived antigenically related clones of T. brucei by sequencing VSG cDNA from ea...
Topics
- Amino Acid Sequence
- Animals
- Antigenic Variation
- Antigens, Protozoan
- Antigens, Surface
- Base Sequence
- DNA, Protozoan
- Epitopes
- Molecular Sequence Data
- Mosaicism
- Multigene Family
- Mutation
- Trypanosoma brucei brucei
- Variant Surface Glycoproteins, Trypanosoma