Article
Location of neutralizing epitopes on the hemagglutinin-esterase protein of influenza C virus.
Virology - 1 Jul 1992
Matsuzaki M, Sugawara K, Adachi K, Hongo S, Nishimura H, Kitame F, Nakamura K
Abstract excerpt
Neutralization-resistant variants of influenza C/Ann Arbor/1/50 virus were selected with monoclonal antibodies against four different antigenic sites on the hemagglutinin-esterase (HE) glycoprotein, and their HE genes were sequenced to identify amino acid residues important for the integrity of each site. Twelve different amino acid substitutions in a total of 18 antigenic variants were all located on the HE1...
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