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Article

Specific stimulation of human apurinic/apyrimidinic endonuclease by heat shock protein 70.

DNA repair - 1 Mar 2003

Mendez Frances, Sandigursky Margarita, Kureekattil Raichal P, Kenny Mark K, Franklin William A, Bases Robert

Abstract excerpt

We previously demonstrated the stimulation of human apurinic/apyrimidinic endonuclease 1 (HAP1) by heat shock protein 70 (HSP70). In this work, we further defined the functional interaction between these proteins. Digestion of HSP70 by trypsin released 48 and 43 kDa amino terminal fragments that retained the ability to stimulate HAP1. In agreement with this result, an HSP70 N-terminal deletion mutant protein...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12547389
DOI: 10.1016/s1568-7864(02)00215-x

Genes

HAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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