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Article

The evolution of the amplified adenylate deaminase 2 domains in Chinese hamster cells suggests the sequential operation of different mechanisms of DNA amplification.

Mutation research - 1 May 1992

Toledo F, Smith K A, Buttin G, Debatisse M

Abstract excerpt

Fluorescent in situ hybridization was used to localize the adenylate deaminase 2 (AMPD2) genes and flanking sequences on the chromosomes of the Chinese hamster line GMA32 and to study the distribution of additional copies of these genetic sequences in amplified mutants selected at several early stages of the amplification process. The synteny of AMPD2 genes and MDR1 genes, located on chromosomes 1, was...

Topics

AMP Deaminase
Animals
Cell Line
Chromosomes
Coformycin
Cricetinae
Cricetulus
Drug Resistance
Fluorescence
Gene Amplification
Mutation
Nucleic Acid Hybridization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombination, Genetic

Sister Chromatid Exchange

Source

Identifiers

PMID: 1374518
DOI: 10.1016/0165-1110(92)90012-x

Genes

AMPD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1374518-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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