Article
Telomeric and nontelomeric (TTAGGG)n sequences in gene amplification and chromosome stability.
Genomics - 1 Nov 1994
Bertoni L, Attolini C, Tessera L, Mucciolo E, Giulotto E
Abstract excerpt
We have isolated eight PALA-resistant mutants from CHO-PV cells and have shown that the CAD gene was amplified. We then localized the CAD genes with fluorescence in situ hybridization followed by G-banding and identified 10 different marker chromosomes carrying amplified DNA. TTAGGG repetitions,...
Topics
- Animals
- Aspartate Carbamoyltransferase
- Aspartic Acid
- CHO Cells
- Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)
- Cells, Cultured
- Cricetinae
- DNA Primers
- Dihydroorotase
- Drug Resistance
- Fibroblasts
- Gene Amplification
- In Situ Hybridization, Fluorescence
- Multienzyme Complexes
- Mutation
- Phosphonoacetic Acid
- Telomere