Article
Modulation of homeobox gene expression alters the phenotype of human hematopoietic cell lines.
The EMBO journal - 1 Mar 1992
Shen W F, Detmer K, Mathews C H, Hack F M, Morgan D A, Largman C, Lawrence H J
Abstract excerpt
We have previously reported that certain genes of the HOX2 cluster of homeobox genes on human chromosome 17 are specifically expressed in human leukemic cell lines with erythroid potential, suggesting that these genes are involved in hematopoietic differentiation. We now show that the expression...
Topics
- Blotting, Northern
- Cell Differentiation
- Chromosomes, Human, Pair 17
- Gene Expression
- Genes, Homeobox
- Genetic Vectors
- Globins
- Granulocyte-Macrophage Colony-Stimulating Factor
- Hematopoietic Stem Cells
- Heme
- Humans
- Leukemia
- Phenotype
- RNA
- Transcription, Genetic