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Article

Do the ends justify the mean? Proline mutations at the ends of the keratin coiled-coil rod segment are more disruptive than internal mutations.

The Journal of cell biology - 1 Mar 1992

Letai A, Coulombe P A, Fuchs E

Abstract excerpt

Intermediate filament (IF) assembly is remarkable, in that it appears to be self-driven by the primary sequence of IF proteins, a family (40-220 kd) with diverse sequences, but similar secondary structures. Each IF polypeptide has a central 310 amino acid residue alpha-helical rod domain, involved in coiled-coil dinner formation. Two short (approximately 10 amino acid residue) stretches at the ends of this rod...

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Source

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Identifiers

PMID: 1371287
DOI: 10.1083/jcb.116.5.1181
PMCID: PMC2289357

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Source receipt: pubmed, retrieved 7 Sept 2026.

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