Article
Do the ends justify the mean? Proline mutations at the ends of the keratin coiled-coil rod segment are more disruptive than internal mutations.
The Journal of cell biology - 1 Mar 1992
Letai A, Coulombe P A, Fuchs E
Abstract excerpt
Intermediate filament (IF) assembly is remarkable, in that it appears to be self-driven by the primary sequence of IF proteins, a family (40-220 kd) with diverse sequences, but similar secondary structures. Each IF polypeptide has a central 310 amino acid residue alpha-helical rod domain, involve...
Topics
- Amino Acid Sequence
- Cells, Cultured
- Epidermolysis Bullosa Simplex
- Humans
- Intermediate Filament Proteins
- Keratinocytes
- Keratins
- Molecular Sequence Data
- Mutation
- Phenotype
- Proline
- Protein Conformation
- Transfection