Article
Excessive glycine loop variations in the keratin 10 tail domain and implications for skin fragility.
The British journal of dermatology - 18 Feb 2026
Mi Zihao, Yu Yueqian, Wang Zhenzhen, Bai Fuxiang, Yu Gongqi, Li Bingqing, Dai Yuanji, Lin Yingjie, Sang Xu, Han Jinghong, Tu Xiaojiao, Wang Yi, Cao Nan, Liu Hong, Zhang Furen
Abstract excerpt
BACKGROUND: Keratins are vital structural proteins in the formation of intermediate filaments (IFs). Dysfunctional keratins lead to various inherited skin fragilities. The keratin tail domain is essential for the proper functioning of IFs, with glycine loop variability prominent in certain keratin tails. However, the effects of glycine loop variations on the functioning of IFs, and the pathogenicity of excessive...
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