Article
CpG methylated minichromosomes become inaccessible for V(D)J recombination after undergoing replication.
The EMBO journal - 1 Jan 1992
Hsieh C L, Lieber M R
Abstract excerpt
The physical parameters controlling the accessibility of antigen receptor loci to the V(D)J recombination activity are unknown. We have used minichromosome substrates to study the role that CpG methylation might play in controlling V(D)J recombination site accessibility. We find that CpG methylat...
Topics
- Animals
- Cell Line, Transformed
- Chromatin
- Chromosome Mapping
- Chromosomes
- DNA Replication
- DNA-Cytosine Methylases
- Deoxyribonuclease HpaII
- Deoxyribonucleases, Type II Site-Specific
- Gene Expression Regulation, Viral
- Genetic Variation
- Mice
- Models, Genetic
- Polyomavirus
- Receptors, Antigen
- Recombination, Genetic