Article
Recessive dystrophic epidermolysis bullosa phenotype is preserved in xenografts using SCID mice: development of an experimental in vivo model.
The Journal of investigative dermatology - 1 Feb 1992
Kim Y H, Woodley D T, Wynn K C, Giomi W, Bauer E A
Abstract excerpt
Recessive dystrophic epidermolysis bullosa (RDEB) is a subgroup of hereditary blistering diseases characterized by repetitive wounding and healing with subsequent extensive scarring. The purpose of this study was to establish a xenograft model that retains the RDEB phenotype and thus might be use...
Topics
- Adolescent
- Adult
- Animals
- Antibodies
- Basement Membrane
- Child
- Collagen
- Disease Models, Animal
- Epidermolysis Bullosa Dystrophica
- Fluorescent Antibody Technique
- Genes, Recessive
- Graft Survival
- Humans
- Male
- Mice
- Mice, SCID
- Phenotype
- Staining and Labeling