Article
Correction of dog dystrophic epidermolysis bullosa by transplantation of genetically modified epidermal autografts.
The Journal of investigative dermatology - 1 Oct 2011
Gache Yannick, Pin Didier, Gagnoux-Palacios Laurent, Carozzo Claude, Meneguzzi Guerrino
Abstract excerpt
Recessive dystrophic epidermolysis bullosa (RDEB) is a severe skin blistering condition caused by mutations in the gene coding for collagen type VII. Genetically engineered RDEB dog keratinocytes were used to generate autologous epidermal sheets subsequently grafted on two RDEB dogs carrying a homozygous missense mutation in the col7a1 gene and expressing baseline amounts of the aberrant protein. Transplanted...
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