Article
Construction of skin equivalents for gene therapy of recessive dystrophic epidermolysis bullosa.
Human gene therapy - 1 Oct 2004
Gache Yannick, Baldeschi Christine, Del Rio Marcela, Gagnoux-Palacios Laurent, Larcher Fernando, Lacour Jean-Philippe, Meneguzzi Guerrino
Abstract excerpt
We have shown that retroviral vectors efficiently transfer the 9-kb collagen type VII cDNA into keratinocytes of dogs with recessive dystrophic epidermolysis bullosa (RDEB) and achieve correction of the RDEB phenotype in vitro. As a next step toward gene therapy applications, we have assessed the suitability of retroviral vectors to transduce human collagen type VII cDNA into primary human RDEB keratinocytes and...
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