Article

Injection of genetically engineered fibroblasts corrects regenerated human epidermolysis bullosa skin tissue

2003-01-15

Abstract excerpt

Current therapeutic strategies for genetic skin disorders rely on the complex process of grafting genetically engineered tissue to recipient wound beds. Because fibroblasts synthesize and secrete extracellular matrix, we explored their utility in recessive dystrophic epidermolysis bullosa (RDEB), a blistering disease due to defective extracellular type VII collagen. Intradermal injection of RDEB fibroblasts overex...

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Literature Corpus work: cee61de1-424e-5db6-9d45-ce284306403d
DOI: 10.1172/jci200317193

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