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Article

Central rod domain insertion and carboxy-terminal fusion mutants of human cytokeratin K19 are incorporated into endogenous keratin filaments.

The Journal of investigative dermatology - 1 Jan 1992

Rorke E A, Crish J, Eckert R L

Abstract excerpt

Keratins comprise a multigene family of structural proteins that form the 10-nm filaments present in epithelial cells. Keratin filament formation requires the presence of stoichiometric quantities of type I and type II keratin peptides. Each keratin peptide contains an N-terminal "head" segment, a C-terminal "tail" segment, and a highly conserved, alpha-helical central rod domain. To investigate the importance of...

Topics

Amino Acid Sequence
Animals
CHO Cells
Cell Line
Cricetinae
Galactosidases
Humans
Intermediate Filaments
Keratins
Macropodidae
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Protein Conformation

Recombinant Fusion Proteins

Transfection

Vimentin

Source

Identifiers

PMID: 1370230
DOI: 10.1111/1523-1747.ep12494161

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1370230-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Central rod domain insertion and carboxy-terminal fusion mutants of human cytokeratin K19 are incorporated into endogenous keratin filaments.PMID 1370230Read ↗

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