Article
Genetic breeding of L-tyrosine producer from Brevibacterium lactofermentum.
Agricultural and biological chemistry - 1 Mar 1990
Ito H, Sakurai S, Tanaka T, Sato K, Enei H
Abstract excerpt
A wild-type parent of Brevibacterium lactofermentum was converted into an L-Tyr producer by three steps of genetic breeding. First, acquirement of m-fluoro-D, L-phenylalanine resistance (1,000 microgram/ml) brought about MF1317 which produced 3.5 g/l of L-Tyr and a byproduct of 2.8 g/l of L-Phe. Second, increase in the drug resistance (5,000 microgram/ml) gave MF358 that produced 6.4 g/l of L-Tyr and a byproduct...
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