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Article

Melanin production in Escherichia coli from a cloned tyrosinase gene.

Bio/technology (Nature Publishing Company) - 1 Jul 1990

della-Cioppa G, Garger S J, Sverlow G G, Turpen T H, Grill L K

Abstract excerpt

We have cloned and functionally expressed a tyrosinase gene from Streptomyces antibioticus in Escherichia coli under the control of an inducible bacteriophage T7 promoter. Recombinant E. coli cells containing the induced tyrosinase gene produced melanin pigments on agar plates and in liquid culture when supplemented with copper and tyrosine. The expression of an additional open reading frame from the mel gene...

Topics

Cloning, Molecular
Escherichia coli
Melanins
Monophenol Monooxygenase
Open Reading Frames
Phenotype
Plasmids
Streptomyces antibioticus
Transformation, Bacterial

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1367455
DOI: 10.1038/nbt0790-634

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1367455-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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