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Article

Ascorbic acid increases drug accumulation and reverses vincristine resistance of human non-small-cell lung-cancer cells

1 Aug 1994

Abstract excerpt

A human lung-cancer PC-9 subline with acquired resistance to vincristine (VCR), a chemotherapeutic agent, was established with incremental increases of the drug. The resistant PC-9 subline (PC-9/VCR) shows a 12-fold increase in resistance to VCR and a unique cross-resistance pattern: high cross-resistance to the potent VCR analogue colchicine (6.9-fold) and vinblastine (2.5-fold); lower cross-resistance to...

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Identifiers

PMID: 7914401
DOI: 10.1042/bj3010759

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