Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multidrug resistance characterization in multicellular tumour spheroids from two human lung cancer cell lines

23 Apr 2015

Abstract excerpt

BACKGROUND: Most of the knowledge about the mechanisms of multidrug resistance in lung cancer has been achieved through the use of cell lines isolated from tumours cultivated either in suspensions of isolated cells or in monolayers and following exposition to different cytostatic agents. However, tumour cell lines growing as multicellular tumour spheroids (MTS) frequently develop multicellular resistance in a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer Research and Treatments
Share to Drug Transport and Resistance Mechanisms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26221079
DOI: 10.1186/s12935-015-0200-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multidrug resistance characterization in multicellular tumour spheroids from two human lung cancer cell linesPMID 26221079Read ↗

Comparison of EMT-Related and Multi-Drug Resistant Gene Expression, Extracellular Matrix Production, and Drug Sensitivity in NSCLC Spheroids Generated by Scaffold-Free and Scaffold-Based MethodsSemantic proximity Read ↗

Application of an Integrated Single-Cell and Three-Dimensional Spheroid Culture Platform in Investigating Drug Resistance Heterogeneity and EMT in Lung Cancer SubclonesSemantic proximity Read ↗

Multiple drug-resistance in variant of a human non-small cell lung carcinoma cell line, DLKP-A.Semantic proximity Read ↗

Application of an Integrated Single-Cell and Three-Dimensional Spheroid Culture Platform for Investigating Drug Resistance Heterogeneity and Epithelial–Mesenchymal Transition (EMT) in Lung Cancer SubclonesSemantic proximity Read ↗

3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugsSemantic proximity Read ↗

Spheroid Morphology of Lung Cancer Cell Lines Correlates with Oncological ProfilesSemantic proximity Read ↗

Overlapping phenotypes of multidrug resistance among panels of human cancer-cell linesSemantic proximity Read ↗

KRAS and EGFR Mutations Differentially Alter ABC Drug Transporter Expression in Cisplatin-Resistant Non-Small Cell Lung Cancer.Semantic proximity Read ↗

Rapid Acquisition of Multicellular Drug Resistance After a Single Exposure of Mammary Tumor Cells to Antitumor Alkylating AgentsSemantic proximity Read ↗

Expression of the multidrug resistance-associated protein (MRP) and chemoresistance of human non-small-cell lung cancer cellsSemantic proximity Read ↗

An etoposide-resistant lung cancer subline overexpresses the multidrug resistance-associated protein.Semantic proximity Read ↗

Non-P-glycoprotein-mediated multidrug resistance with reduced EGF receptor expression in a human large cell lung cancer cell line.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.