Article
cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes.
Nature - 18 Sept 2003
Davidson Alan J, Ernst Patricia, Wang Yuan, Dekens Marcus P S, Kingsley Paul D, Palis James, Korsmeyer Stanley J, Daley George Q, Zon Leonard I
Abstract excerpt
Organogenesis is dependent on the formation of distinct cell types within the embryo. Important to this process are the hox genes, which are believed to confer positional identities to cells along the anteroposterior axis. Here, we have identified the caudal-related gene cdx4 as the locus mutated in kugelig (kgg), a zebrafish mutant with an early defect in haematopoiesis that is associated with abnormal...
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