Article
Phenothiazines as potent modulators of yeast multidrug resistance.
International journal of antimicrobial agents - 1 Sept 2003
Kolaczkowski Marcin, Michalak Krystyna, Motohashi Noboru
Abstract excerpt
Active efflux of antifungal, antibacterial and anticancer drugs by broad-specificity multidrug resistance (MDR) transporters are major obstacles to successful chemotherapy of infectious diseases and cancer. We evaluated the growth inhibitory and MDR modulatory effect of a series of 36 phenothiazines and related compounds, against Saccharomyces cerevisiae strains exhibiting different levels of expression of MDR...
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