Phenotypic yeast growth analysis for chronic toxicity testing.

Abstract excerpt

In Saccharomyces cerevisiae the pH-dependent growth inhibition of the heavy metals Cu(2+), Cr(6+), Zn(2+), Co(2+), and Cd(2+) was examined in comparison to that of organic solvents and pure compounds DMSO, MNNG, 4-NQO, MTBE, ethanol, and 2-AA. The assay was based on both S. cerevisiae wild-type and genetically modified cells deleted in the transporters Pdr5, Snq2, and Yor1 that facilitate pleiotropic drug...

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