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Article

p120 catenin recruits cadherins to gamma-secretase and inhibits production of Abeta peptide.

The Journal of biological chemistry - 23 Jan 2009

Kouchi Zen, Barthet Gael, Serban Geo, Georgakopoulos Anastasios, Shioi Junichi, Robakis Nikolaos K

Abstract excerpt

The gamma-secretase complex cleaves many transmembrane proteins, including amyloid precursor protein, EphB and ErbB tyrosine kinase receptors, Notch1 receptors, and adhesion factors. Presenilin 1, the catalytic subunit of gamma-secretase, associates with the cadherin/catenin cell-cell adhesion/communication system and promotes cadherin processing (Georgakopoulos, A., et al. (1999) Mol. Cell 4, 893-902; Marambaud,...

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Share to Amyloid beta-Peptides
Share to Amyloid Precursor Protein Secretases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cadherins

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Source

Open in PubMed Open full text

Identifiers

PMID: 19008223
DOI: 10.1074/jbc.M806250200
PMCID: PMC2629097

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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